Clinical algorithm for treatment of Plasmodium falciparum malaria in children
نویسندگان
چکیده
منابع مشابه
The Use of Crude Plasmodium falciparum Antigens for Comparison of Antibody Responses in Patients with Mild Malaria vs. Cerebral Malaria
Background: Cerebral malaria (CM) is one of the major causes of death in African populations infected with Plasmodium falciparum. Only 1% of infected subjects develop CM. The reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens plays a role in protection from malaria, although the precise targets and mechanisms medi...
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Background: This paper reports for the first time, the antimalarial efficacy of a five-day course of paediatric formulation of “vocamine” named MMH8 from Millenia Hope Inc for the treatment of uncomplicated Plasmodium falciparum malaria. Methods: We used the standard 14-day WHO protocol to assess therapeutic responses in children less than 5 years in Bangui (Central African Republic) between Ja...
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We conducted a study in Binh Phuoc, Vietnam, in 2015 on the therapeutic efficacy of dihydroartemisinin/piperaquine for Plasmodium falciparum malaria. A high number of treatment failures (14/40) was found, and piperaquine resistance in Vietnam was confirmed. A change in the malaria treatment policy for Vietnam is in process.
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Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood ma...
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It has been demonstrated that fosmidomycin has good tolerability and rapid onset of action, but late recrudescences preclude its use alone; in vitro, clindamycin has been shown to act synergistically with fosmidomycin against Plasmodium falciparum. We conducted a study in pediatric outpatients with P. falciparum malaria in Gabon to evaluate the efficacy and safety of an oral combination of fosm...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1996
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(96)90404-3